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A 45-Year Follow-Up

ALVAN R. SCHWARTZ, MD

Arch Neurol. 1963;9(6):623-634.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Charcot-Marie-Tooth disease (CMTD), or peroneal muscular atrophy (PMA), is an uncommon inherited affection of peripheral nerve and probably root, spinal cord, and muscle of young people. Many aspects of the pathology, etiology, and genetics are unresolved and demand a review of previous findings as well as new approaches in future investigations. In this light, a family containing five male siblings with this illness has been studied. From a review of the literature, it appears this is the first time that: (1) a 45-year follow-up study of this progressive disorder has been attempted; (2) chromosomal analysis has been performed in this heredofamilial disease; and (3) adequate documentation of the associated mental deficiency has been obtained, whereas previous reports have only noted impressions of such. In addition, the development of concepts and controversies regarding certain genetic, pathological, and clinical aspects has been chronologically summarized.

Report of Cases

Present Illness and Family History . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Department of Neurology, Lemuel Shattuck Hospital, Boston.

Footnotes
Submitted for publication July 10, 1963; accepted Aug 9.

Portions of this paper were presented at Newton-Wellesley Hospital, Newton, Mass, June 13, 1962.

Present address: Department of Neurology, Boston City Hospital, Boston.

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