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Clinical Measurement of Brain Uptake of Radioisotope
WILLIAM H. OLDENDORF, MD;
MASAMI KITANO, MD
Arch Neurol. 1963;9(6):574-585.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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During the course of some studies of cerebral circulation using  -emitting radioisotopes injected intravenously we were interested in following the passage through the brain of a -emitting radioisotope deposited abruptly into the right heart. Ideally the indicator that passes through the brain would remain entirely intravascular. Because of its extremely rapid renal excretion the substance we felt most desirable was o-iodinated sodium hippurate. We were interested in how well this material remained intravascular in the brain. As a consequence of this interest we developed the technique to be described. Our early experience with labeled hippurate has been described.1
Technique
The technique consists of giving a small amount of -emitting radioisotope intravenously and following the total cranial content as the blood level falls. Initially the entire cranial content will be in the circulating blood pool and none in the noncirculating tissues. By subtracting the blood contribution to the total
. . . [Full Text PDF of this Article]
Author Affiliations
LOS ANGELES
From the Neurology Section, Veterans Administration Center, and the Department of Medicine, University of California at Los Angeles.
Footnotes
Submitted for publication July 31, 1963; accepted Aug 29.
Presented at the Eighty-Eighth Annual Meeting of the American Neurological Association, Atlantic City, NJ, June 10, 1963.
Assistant Clinical Professor of Medicine (Neurology), UCLA School of Medicine (Dr. Oldendorf); Assistant Research Neurologist, UCLA School of Medicine (Dr. Kitano).
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