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Neurologic Complications of Myelomatosis
ALLEN SILVERSTEIN, MD;
DAVID E. DONIGER, MD
Arch Neurol. 1963;9(5):534-544.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Although the nervous system manifestations of multiple myeloma have been described previously,1-9 there still remains some controversy concerning the incidence, pathogenesis, and treatment of the several types of neurologic complications of the disease. Many of the previous publications of the neurologic aspects of myelomatosis were based on observations of small series of patients who were sometimes specially selected (eg, those admitted to a neurosurgical service). The emphasis of many of the previous reports has been either on the direct compression of the nervous system by myeloma tumor or on distant "toxic" effects. In the older literature, the criteria for the diagnosis of multiple myeloma have, at times, also been uncertain.
The purpose of this communication is to report and discuss the neurologic complications observed in 277 patients admitted to a general hospital, where a diagnosis of multiple myeloma was eventually proved.
Materials and Methods
The 277 patients were all
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
Departments of Neurology and Hematology, The Mount Sinai Hospital.
Footnotes
Submitted for publication July 12, 1963; accepted July 31.
Aided in part by USPHS grants CA-04457 (National Cancer Institute) and AM-04434 (National Institute of Arthritis and Metabolic Diseases) and the Albert A. List, Frederick Machlin and Anna Ruth Lowenberg Funds.
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