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Medulloblastoma With Extracranial Metastases
DAVID A. DRACHMAN, MD;
THORNE S. WINTER III, MD;
MYRON KARON, MD
Arch Neurol. 1963;9(5):518-530.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Introduction
Medulloblastoma cerebelli is a common brain tumor of the childhood years whose incidence in this age group is exceeded only by astrocytomas.1,2 It is estimated that approximately 200 cases occur in the United States alone each year.3 Because of the almost invariably fatal course of medulloblastoma many cases have been examined at necropsy; the poor encapsulation of the tumor, local invasiveness and primitive appearance of the cells invariably meet the histologic criteria for malignancy. Matastases within the central nervous system have been seen in one third to one half the cases where a careful search of brain, spinal cord, and nerve roots has been carried out.4-6 Yet, only eight instances of medulloblastoma metastasizing outside the central nervous system have been reported in which the diagnosis has been established by complete postmortem examinations.
The purpose of this communication is to report an additional autopsied case of medulloblastoma
. . . [Full Text PDF of this Article]
Author Affiliations
BETHESDA, MD
From the Medical Neurology Branch, National Institute of Neurological Diseases and Blindness (Dr. Drachman), and the Medicine Branch, National Cancer Institute (Dr. Winter, Dr. Karon), National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.
Footnotes
Submitted for publication June 26, 1963; accepted July 1.
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