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MARK A. GOLDBERG, MD; CHARLES F. BARLOW, MD; LLOYD J. ROTH, MD

Arch Neurol. 1963;9(5):498-507.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Carbon dioxide narcosis is a recognized phenomenon of the laboratory and in neurological practice.¹ Hypercapnia is known to produce changes in the EEG,² to dilate cerebral blood vessels,³ and to increase cerebral blood flow.⁴ The effect of hypercapnia on brain metabolism and permeability has been less intensively studied. In this report we have studied the effects of CO₂ on brain permeability using sodium S³⁵ sulfate and C¹⁴ urea as indicators, employing the methodologies of regional radioassay and autoradiography.

Methods

S³⁵ sodium sulfate (Abbott Laboratories, Chicago, "carrier free") was administered intravenously to cats in the following dosage: 1 or 2 mc/kg for animals sacrificed after 5 min and 0.5 or 1 mc/kg for animals sacrificed after 1 and 6 hr. The differing dosage of radioactivity did not affect the results, but the higher radioactive dose was more satisfactory for metabolite separation. The . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine (Neurology) and the Department of Pharmacology, The University of Chicago.

Footnotes
Submitted for publication June 21, 1963; accepted July 16.

Presented in part before the Annual Meeting of the American Neurological Association, Atlantic City, June, 1963.

This work was supported by grant B-2331 of the Institute for Neurological Diseases and Blindness, National Institutes of Health.

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