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Location of Brain Tumors With Polyvinylpyrrolidone-I131
PAUL J. PITLYK, MD;
W. NEWLON TAUXE, MD;
FREDERICK W. L. KERR, MD;
RICHARD E. SEDLACK, MD;
HENDRIK J. SVIEN, MD
Arch Neurol. 1963;9(4):437-443.
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In recent years, improvements in instrumentation (collimators, mechanical scanning devices, and so forth) and the availability of a greater variety of radioactive isotopes and substances labelled with isotopes have led to renewed optimism regarding the use of scanning methods for locating intracranial tumors. To the clinician these methods represent a valuable adjunct to standard contrast studies, and to the patient, a more tolerable diagnostic procedure.
Various agents, including arsenic, copper, potassium, phosphorus, iodoalbumin, and sodium iodide, have been used, paralleling progressive refinement of detection systems.1-7 However, results have been of limited value, until the recent introduction of chlormerodrin,8 with accuracy remaining considerably below that afforded by the classical contrast studies. Part of the reason for this failure is the accumulation of the tracer agents in muscle, thereby interfering with detection of lesions in the posterior fossa deep to the suboccipital musculature. Also there has been concern about irradiation
. . . [Full Text PDF of this Article]
Author Affiliations
ROCHESTER, MINN
Fellow in Neurosurgery, Mayo Foundation (Dr. Pitlyk); Section of Clinical Pathology (Dr. Tauxe), Section of Neurologic Surgery (Dr. Kerr), Section of Medicine (Dr. Sedlack), Section of Neurologic Surgery (Dr. Svien), Mayo Clinic and Mayo Foundation.
Footnotes
Submitted for publication June 5, 1963.
This investigation was supported in part by Research grant B-3296 from the National Institutes of Health, Public Health Service.
Abridgment of thesis submitted by Dr. Pitlyk to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Neurosurgery.
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