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A Study of Infantile Spasms, Diffuse Encephalopathies, and Experimental Lesions of the Brain

PAUL F. A. HOEFER, MD; ROBERT A. deNAPOLI, MD; STANLEY LESSE, MD

Arch Neurol. 1963;9(4):424-436.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In 1956 and 1958 Lesse, Hoefer, and Austin^1,2 reported on clinical and electroencephalographic (EEG) findings in 11 patients suffering from a variety of diffuse encephalopathies of different etiologies and clinical outcome, but with a common EEG abnormality, namely, periodic synchronous bursts of irregular slow and spike-and-wave activity, mainly of high amplitude and with depression of activity in the interval. It was our impression that the EEG pattern was related to a profound cerebral, chiefly cortical, disturbance. The clinical features of this disturbance are: organic mental changes, myoclonic and generalized convulsions, rigidity, and a choreo-athetoid form of dyskinesia. Earlier authors^3,4 had considered the EEG pattern to be specific for subacute sclerosing leukoencephalitis of the Dawson⁵ and van Bogaert⁶ varieties. Only one of our own original cases fell into this category, and we concluded that the clinical picture was indicative of a state of physiological impairment with . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital.

Footnotes
Submitted for publication May 27, 1963; accepted July 16.

Professor of Neurology (Dr. Hoefer); Instructor in Neurology (Dr. deNapoli); Associate in Neurology (Dr. Lesse).

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