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Spontaneous and Drug-Induced Changes in Flow and Vascular Diameter

WILLIAM I. ROSENBLUM, MD; BENJAMIN W. ZWEIFACH, PhD

Arch Neurol. 1963;9(4):414-423.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several reports indicate that agents which can be topically applied to the vessels on the cerebral surface, and which have marked vasoconstrictive properties in other vascular beds, produce only minimal effects on the cerebral vessels.^1-3 For example, the response of the cerebrovascular bed to catechol amines is so poor as to provide a totally inadequate representation of vascular reactivity. Cerebral arteries are capable of much greater alterations of diameter as shown by their responses to respiratory gases.^4-6 The problem of studying cerebroarterial reactivity is made even more difficult when small vessels are examined, since their size precludes reliable estimation of the small changes in diameter which may follow stimulation with epinephrine or levarterenol (norepinephrine). Moreover, several authors report only variable or inconsistent effects of catechols on the smaller pial arteries or arterioles.^2,3 There is little doubt that it is important to study further the reactivity of these . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the departments of pathology, Bellevue Hospital and New York University School of Medicine.

Footnotes
Submitted for publication May 29, 1963; accepted July 9, 1963.

Supported by a Training Fellowship under USPHS Pathology Research Training grant 2G-127 and Neuropathology Training grant 2B-5095 (Dr. Rosenblum); Recipient of Investigatorship Award, New York City Health Research Council (I-141) Professor of Pathology, New York University School of Medicine (Dr. Zweifach).

Supported by grants from the United States Public Health Service, H-7289, and from the United States Vitamin Corporation.

The compound.1-(p-phydroxyphenyl)-2-(1-methyl-3-phenylpropylamino) propanol hydrocholoride, supplied as Arlidin by U.S. Vitamin and Pharmaceutical Corporation, New York.

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