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Part II. Histopathological Results

YUJI MIYAZAKI, MD; FRANK R. ERVIN, MD; JEAN SIEGFRIED, MD; EDWARD P. RICHARDSON, MD; VERNON H. MARK, MD

Arch Neurol. 1963;9(4):392-399.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The recent progress in clinical stereotactic surgery has largely been the result of detailed human brain atlases, effective procedures for making discrete brain lesions, and improved lightweight accurate stereotactic machines. These advances rely on the correlation of neuroanatomical landmarks with the radiographic ventricular outline. The individual variations in human brains plus the necessity of translating ventriculothalamic measurements obtained from the cadaver to the living patient give less than perfect accuracy in placing a stereotactic lesion within the cerebral target area. This is particularly true when the target area lies in the thalamus of a patient with infantile choreoathetosis, since diffuse brain pathology often distorts the relation of the target area to ventricular landmarks. In this situation, the necessity of using neurophysiological guides is apparent. Stimulation, recording of evoked potentials, and the production of reversible brain lesions have been the three standard physiological guides used by stereotactic surgeons. Our group . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Departments of Psychiatry and Pathology and the Neurosurgical Service, Massachusetts General Hospital, and the Departments of Surgery, Psychiatry, and Pathology, Harvard Medical School, Boston, Massachusetts.

Footnotes
Submitted for publication April 26, 1963; accepted June 8.

Present Address: Department of Neurosurgery, Sapporo Medical College and Hospital, S1, W-16, Sapporo, Japan (Dr. Miyazaki).

This work was supported by Grant No. NB-03425 from the National Institutes of Health, a grant from the United Cerebral Palsy Association, and the Hall-Mercer Fund.

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