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Experimental "Petit Mal" in Kittens
R. GUERRERO-FIGUEROA, MD;
A. BARROS, MD;
F. de BALBIAN VERSTER, PhD;
ROBERT G. HEATH, MD
Arch Neurol. 1963;9(3):297-306.
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The experimental production of epileptogenic cortical foci in monkeys by means of local application of alumina cream to the cortex was initially described by Kopeloff, Barrera, and Kopeloff1 in 1942. The technique does not readily lend itself, however, to the creation of focal deep lesions, since the fluid irritative agent backs up through the needle tract and often spreads through the ventricles or subarachnoid spaces. In our laboratories a method was introduced to produce epileptogenic foci in deep structures of the brain.2 Crystalline aluminum oxide was stereotaxically introduced into specific subcortical structures of the brain. A primary epileptogenic focus developed at the site of the alumina, and, subsequently, secondary discharge developed in the homotopic structure of the contralateral hemisphere.
This report is concerned with the induction of petit mal-like patterns after the introduction of crystalline aluminum oxide into deep structures of the brains of kittens. Reports in the
. . . [Full Text PDF of this Article]
Author Affiliations
NEW ORLEANS
Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans, Southeast Louisiana Hospital, Mandeville, La.
Footnotes
Submitted for publication March 19, 1963; accepted June 8.
This work was supported in part by General Research Support Grant, Tulane University (22662), and in part by funds provided by the Louisiana State Department of Hospitals.
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