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Further Observations on Triethyltin Edema
ROBERT KATZMAN, MD;
FERNANDO ALEU, MD;
CLARENCE WILSON, BS
Arch Neurol. 1963;9(2):178-187.
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Fatal triethyltin intoxication is characterized by the presence of marked edema throughout the neuraxis. In electron micrographs of the neuropil of the mouse this edema occurs as swelling of the glial cell cytoplasm, the typical change observed in neuropil with edema produced by various agents.33,34 A unique form of cerebral edema was reported by Aleu, Katzman, and Terry3 in studies of the white matter of rabbits poisoned with triethyltin. Electron micrographs showed the development of massive loculated collections of fluid contained within myelin sheaths. The myelin sheath was split, usually toward the outer lamellae, at an interperiod line. This line is formed by the apposed plasma membrane of the myelin forming cell. Thus, the interperiod line may indicate the site of a potential extracellular space. However, no connection between these vacuoles and the extracellular space was apparent. Nor was there appreciable alteration of the extracellular space. Chemical analysis
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
From the Departments of Neurology and Pathology, Albert Einstein College of Medicine.
Post Doctoral Fellow in Neuropathology (Dr. Aleu), NIH grant BT-806.
Footnotes
Submitted for publication March 22, 1963; accepted May 6, 1963.
Post Doctoral Fellow in Neuropathology (Dr. Aleu), NIH grant BT-806.
This work was supported by grants NB-02255 and NB-01450-06, USPHS, and Career Research Program Award NB-K3-17044, USPHS.
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