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JAMES N. HAYWARD, MD; WILBUR K. SMITH, MD

Arch Neurol. 1963;9(2):171-177.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The rate of release of the antidiuretic hormone (ADH) from the neurohypophysis into the hypophysial veins depends upon various factors, among which are osmotic pressure, blood volume, body temperature, and the emotional state. The supraoptic and paraventricular nuclei in the hypothalamus comprise the final common pathway activated by these afferent stimuli. However, the central neural mechanisms and pathways involved in the regulation of ADH release are not well understood.

We have previously shown that the neurohypophysis can be influenced from the mesencephalic tegmentum,¹ a region which has important connections not only with the hypothalamus but also with the medial and basal regions of the forebrain.² The latter two areas, collectively termed the "limbic system,"³ have direct pathways to the hypothalamus⁴ by which they influence somatovisceral⁵ and endocrine functions.⁶ Electrical excitation of parts of the limbic system has induced release of ovulating hormone,⁷ corticotropin . . . [Full Text PDF of this Article]

Author Affiliations
LONG BEACH, CALIF; ROCHESTER, NY

From the Departments of Anatomy, Medicine and Pediatrics, University of Rochester School of Medicine and Dentistry.

Footnotes
Submitted for publication April 4, 1963; accepted May 6, 1963.

Presented in part at the meeting of the American Neurological Association, Atlantic City, June 18, 1962.

USPHS (NINDB) Special Fellow (BT-542) and Senior Instructor in Medicine (Neurology) and Pediatrics (Neurology), University of Rochester School of Medicine and Dentistry (Dr. Hayward).

Professor of Anatomy and Professor of Pediatric Neurology, University of Rochester School of Medicine and Dentistry (Dr. Smith).

Supported by Grants B-3237 and B-1399 from the National Institute of Neurological Diseases and Blindness.

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