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FRANCIS A. ECHLIN, MD; ARTHUR BATTISTA, MD

Arch Neurol. 1963;9(2):154-170.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The present experiments are concerned with further evidence of the epileptogenic properties of chronic partially isolated (denervated) monkey cerebral cortex.

Marshall Hall²⁹ in 1841 remarked, "The first effect of injury done to the nervous system is a diminution of its functions; whilst the second or ulterior effect is the augmentation of those functions." In 1880 Claude Bernard³ stated, "The excitability of all tissues seems to augment when they are separated from the nervous influences which dominate them." In subsequent years there followed a wide series of observations, largely on excitable peripheral structures, confirming and expanding the opinions of Hall and Bernard. In 1939 Cannon,⁹ in his Hughlings Jackson lecture at the Montreal Neurological Institute, presented his Law of Denervation as follows: "When in a series of efferent neurones a unit is destroyed an increased irritability to chemical agents develops in the isolated structure or structures, the effects . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Footnotes
Submitted for publication April 5, 1963; accepted May 3, 1963.

With the technical assistance of Caryl Schmer and Lewis Brown.

Laboratory of Electroencephalography, The Neurosurgical Service and Department of Neurology, Lenox Hill Hospital, and the Department of Neurosurgery, New York University Medical Center. This research was supported by a Public Health Service grant from the National Institute of Neurological Diseases and Blindness, and the Robert Clark Memorial Fund.

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