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II. Serotonin and Catecholamine Levels in Various Cat Brain Areas Following Administration of Psychoactive Drugs or Amine Precursors

P. L. McGEER, MD, PhD; E. G. McGEER, PhD; J. A. WADA, MD

Arch Neurol. 1963;9(1):81-89.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

There have been numerous investigations linking some of the better known central aromatic amines with the actions of various types of psychoactive drugs. Seldom, however, have objective behavioral data and detailed chemical measurements been carried out in the same laboratory. Aprison and Ferster¹ attempted to correlate brain monoamine oxidase activity with pecking behavior in pigeons, and Weissman and Finger² studied the effect of benzquinamide on both conditioned avoidance behavior and brain amine levels in rats and monkeys. Often in correlative drug-behavior studies, such as these, only one central amine has been measured. It may well be that the balance between the amines rather than the absolute level of any one amine is the more important to behavior. In order to provide more precise information regarding central amine levels and behavior, we undertook the measurement of serotonin, norepinephrine, and dopamine in 16 brain areas from cats treated with . . . [Full Text PDF of this Article]

Author Affiliations
VANCOUVER, CANADA

Footnotes
Submitted for publication Dec 6, 1962; accepted March 28, 1963.

Kinsmen Laboratory of Neurological Research, Faculty of Medicine, The University of British Columbia.

This work was supported by Federal-Provincial Mental Health Grant No. 609-5-141 and a grant from the Canadian Mental Health Association.

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