This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (31)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. Conditioned Avoidance Response in Cats, Following Administration of Psychoactive Drugs or Amine Precursors

J. A. WADA, MD; J. WRINCH; D. HILL; P. L. McGEER, MD, PhD; E. G. McGEER, PhD

Arch Neurol. 1963;9(1):69-80.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The significance to behavior of biologically active amines normally present in the mammalian brain has been receiving increased attention by workers in diversified fields in recent years. This trend has been accelerated by the recognition that a number of potent psychotherapeutic agents seem to assert their beneficial effects by influencing these amines in various ways. For example, the tranquillizing agent reserpine is thought to act by depleting the brain of norepinephrine, serotonin, and possibly other amines,^3,9 while the psychic energizing monoamine oxidase inhibitors are thought to act by hindering their destruction.⁴ Phenothiazines are known to block both peripheral and central effects of a number of amines, presumably by competing for receptor sites. Hallucinogenic agents such as lysergic acid diethylamide (LSD-25) and psilocybin also block certain effects of various amines, but many have the additional property of mimicking the actions of other amines.

Relationships between hallucinogenic agents, psychoactive . . . [Full Text PDF of this Article]

Author Affiliations
VANCOUVER, CANADA

Kinsmen Laboratory of Neurological Research, Faculty of Medicine, The University of British Columbia.

Footnotes
Submitted for publication Dec 6, 1962; accepted March 28, 1963.

Medical student research fellows (Mr. Wrinch and Mr. Hill), The University of British Columbia.

Presented at the Seminar on the Physiology and Biochemistry of Disturbed Brain Function, Vancouver, June 15-16, 1961 and the Society of Biological Psychiatry Meetings, Toronto, May 1962.

This work was supported by Federal-Provincial Mental Health Grants No. 609-5-112 and No. 609-5-139, and by the U.S. Public Health Service Grant B-2812.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?