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Vol. V. Price, $10.00 Edited by Robert G. Grenell, Ph.D. Pp. 397, with illustrations. Paul B. Hoeber, Inc., Medical Division of Harper and Row, 49 E. 33d St., New York 16, 1962.

Dominick P. Purpura, M.D., Reviewer

Arch Neurol. 1963;8(4):458-459.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Two objectives were sought in this symposium: to explore the usefulness of abnormal or unphysiological reactions in the study of the properties of excitable cells and to specify the physiological and biochemical processes underlying some pathophysiological activities of single neurons and neuronal aggregates. The 15 papers comprising this volume vary widely in the extent to which they meet these objectives. The spirit of the conference is perhaps best preserved in the papers by Thesleff, Eccles, and Tasaki. These papers discuss experimental data on several important problems, e.g., the role of the motor axon in controlling properties of muscle membrane, the determinants of synaptic organization, and the electrochemical basis of excitation. Tasaki's views on the "fixed negative charge" hypothesis of the nerve membrane are illustrated by several elegant experimental analyses. Somewhat less informative contributions to the analysis of pathophysiological processes in neurons are presented by Merlis in a review of seizure . . . [Full Text PDF of this Article]

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