 |
|
Chlorpromazine-Induced Weakness in Myasthenia Gravis
MICHAEL P. McQUILLEN, M.D.;
MARTIN GROSS, M.D.;
SYKESVILLE, MD;
RICHARD J. JOHNS, M.D.
Arch Neurol. 1963;8(3):286-290.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
In the management of myasthenia gravis, it is important to avoid the use of medications such as curare and quinine which make the neuromuscular block worse. Shortly after the discovery of chlorpromazine, animal studies suggested some actions which might be deleterious to myasthenic patients.1,2,7,9-11 However, no clinical report confirming such adverse effects in myasthenia has appeared.
When a psychotic myasthenic patient became weaker after oral chlorpromazine, study was made of the nature of this worsening. The results of that investigation form the basis of this report.
Report of a Case
This patient was the subject of an extensive report 21 years ago.5 Thus, only findings pertinent to the present study are detailed here.
The patient was born in 1902. He was struck on the head with a baseball bat in 1918 and was unconscious for 5 to 6 hr.; a left peripheral facial paresis was the only sequela.
. . . [Full Text PDF of this Article]
Author Affiliations
BALTIMORE; BALTIMORE
From the Department of Medicine, The Johns Hopkins University School of Medicine and Hospital, Baltimore (Dr. McQuillen and Dr. Johns), and the Springfield State Hospital, Sykesville, Md. (Dr. Gross).
Fellow in Medicine, The Johns Hopkins University (Dr. McQuillen); Research Director, Springfield State Hospital (Dr. Gross); Associate Professor of Medicine, The Johns Hopkins University (Dr. Johns).
Footnotes
Submitted for publication July 12, 1962.
Aided by Grants B-894 and MY-3672 from the National Institute of Neurological Diseases and Blindness, National Institutes of Health, U.S. Public Health Service.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
