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Correlation with Cerebrospinal Fluid and Blood Ammonia Content

CARL B. BOOTH, M.D.; JOHN G. SWADEY, M.D.; ROSA E. FIOL, M.D.; BERNARD KLEIN, Ph.D.; JULIA C. HALL, Ph.D.

Arch Neurol. 1963;8(3):257-263.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A highly suggestive correlation between blood ammonia levels on the one hand and alterations of mental status and characteristic involuntary movements on the other in patients with liver disease has been reported by many workers.^1-5 Complete reviews of our current knowledge of ammonia metabolism have been published recently by Bessman⁶ and by Chalmers.⁷ The concept of a relationship of blood and cerebrospinal fluid (CSF) ammonia levels to neurologic findings apart from mental changes and the typical hepatic "flap," however, has received relatively little attention. In particular, the correlation of specific findings in either the neurologic, general physical, or laboratory examinations of patients with liver disease, with blood or CSF ammonia levels has not, to our knowledge, been the subject of any rigorous study. The principal purpose of this report is to determine whether the ammonia levels of blood and cerebrospinal fluid of patients with liver disease have . . . [Full Text PDF of this Article]

Author Affiliations
BRONX, N.Y.

From the Neurological Section, The Medical and Laboratory Services, and the Psychology Section of the Bronx Veterans Administration Hospital, 130 W. Kingsbridge Road, Bronx 68, N.Y. and from the Division of Neuropathology of the Department of Pathology, College of Physicians and Surgeons, Columbia University.

Footnotes
Received for publication Oct. 8, 1962.

Assistant Clinical Professor of Neurology, College of Physicians and Surgeons, Columbia University, N.Y. (Dr. Booth), and Visiting Assistant Professor of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, N.Y. (Dr. Klein).

This work was supported in part by Neuropathology Training Grant 5B 11-58 from the National Institute of Neurological Diseases and Blindness, United States Public Health Service.

One patient had adenocarcinoma of the liver in addition to hemochromatosis.

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