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Activity of Acid and Alkaline Phosphatase in the Cerebrospinal Fluid

KONSTANTY GUZOWSKI, M.D.; JANINA KNOBLOCH, M.D.

Arch Neurol. 1963;8(1):105-111.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Among the phosphatases, ferments taking part in the phosphorylation processes of the body, the greatest importance is being attributed to acid and alkaline phosphatases. They differ from each other by their properties and also by pH at which they develop their activity. Alkaline phosphatase catalyses the processes occurring in the cell plasma; acid phosphatase catalyses those of the nucleus. Their presence also favors phosphorylation and dephosphorylation processes. Individual tissues may show the predominance of one of the ferments: thus, forinstance, the tissues with increased glycogenolysis processes (liver, muscles, spleen) contain predominant amounts of acid phosphatase, whereas bone tissue, kidneys, and duodenal mucous membrane exhibit a higher level of alkaline phosphatase.

For scientific and diagnostic purposes, the activity of the ferments is being determined in the tissues and body fluids, particularly in blood serum. In normal human serum, the content of alkaline phosphatase is higher than that of acid . . . [Full Text PDF of this Article]

Author Affiliations
WROCLAW, POLAND

From the Neurological Clinic, School of Medicine, Director: Prof. Dr. Rudolf Arend.

Footnotes
Submitted for publication July 12, 1962.

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