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Studies on Glioma Immunity in the Mouse
R. GORDON LONG, M.D.;
JOHN S. O'CONNOR, M.D.;
LAWRENCE F. JELSMA, M.D.
Arch Neurol. 1962;7(6):538-544.
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Introduction
The urgent need for new approaches to the therapy of malignant tumors has prompted renewed interest in the role of immune processes and other host defense mechanisms in neoplastic disease. Although the role of immunological processes in such diseases remains poorly understood, considerable clinical and experimental evidence has been accumulated which indicates that immune mechanisms are of importance in certain types of malignant disease in the human.3,4,8-10
The recognition of the importance of autoimmune processes in certain nonmalignant human diseases has also served to stimulate new interest in immune mechanisms.2,19 In the laboratory animal destructive lesions of certain tissues including brain, peripheral nerve, uveal tract, testicular germinal epithelium, and thyroid have been produced by sensitizing the animal against his own tissues.20 This sensitization has been produced by the combination of adjuvant with appropriate tissue antigen. Adjuvant, containing paraffin oil and killed acid-fast bacilli, has the property
. . . [Full Text PDF of this Article]
Author Affiliations
BALTIMORE
From the Division of Neurological Surgery, The Johns Hopkins University.
Footnotes
Submitted for publication May 29, 1962.
Presented in part at the Houston Neurological Society Symposium on "The Biology and Treatment of Intracranial Tumors," March, 1961.
Supported by an institutional grant from the American Cancer Society.
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