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Periventricular Leukomalacia of InfancyA Form of Neonatal Anoxic Encephalopathy
BETTY Q. BANKER, M.D.;
JEANNE-CLAUDIE LARROCHE, M.D.
Arch Neurol. 1962;7(5):386-410.
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Introduction
The purpose of this report is to draw attention to a unique disease of cerebral white matter which has been encountered with great frequency among infants who died at the Children's Hospital Medical Center, Boston. Despite the remarkably high incidence of periventricular leukomalacia, which is the name that has been chosen for this pathological entity, it has been the subject of relatively little investigation, particularly in respect to the importance of prenatal and neonatal factors in its production and in respect to the clinical manifestations and to the nature of the pathological changes.
Historical Review
In 1843, in a lecture concerning the deformities of the human frame, W. J. Little1 described universal spasmodic contractures of the limbs which he attributed to abnormal factors in the perinatal period. He emphasized that the majority of these infants were born prematurely and had suffered some form of asphyxia at birth and
. . . [Full Text PDF of this Article]
Author Affiliations
BOSTON
Rockefeller Foundation Fellowship, 1958-1959 (Dr. Larroche). Present address: Clinique Baudelocque, Paris, France (Dr. Larroche). Department of Pathology, Cleveland Metropolitan General Hospital, Cleveland 9, Ohio (Dr. Banker).; From the Warren Anatomical Museum and the Department of Neuropathology, Harvard Medical School.
Footnotes
Submitted for publication March 31, 1962.
Presented in part to the American Association of Neuropathologists, Boston, June, 1960.
This work was supported by grants from the National Foundation for Neuromuscular Diseases and the National Institutes of Health, Institute of Neurological Diseases and Blindness—7738-2.
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