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A Topographic Study

ASAO HIRANO, M.D.; H. M. ZIMMERMAN, M.D.

Arch Neurol. 1962;7(3):227-242.

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Introduction

The significance of Alzheimer's neurofibrillary changes has been actively discussed by neuropathologists over the past half a century, and numerous reports have been written concerning it. Their clinicoanatomical correlation with mental disease, their relation to senile plaques and other changes associated with aging, their cytological demonstration with silver impregnation techniques, as well as experimental attempts at their reproduction, have engaged many investigators.

Topographic aspects of this neuronal alteration have been analyzed in certain parts of the central nervous system in a few conditions—the cerebral cortex in Alzheimer's disease and the senile psychoses, and the substantia nigra and brain stem in parkinsonism.

Recent observations of neurofibrillary changes in 2 fatal neurologic diseases occurring on the island of Guam, the parkinsonism-dementia complex (Hirano, Kurland, Krooth, and Lessell¹; Hirano, Malamud and Kurland²) and the amyotrophic lateral sclerosis syndrome (Malamud, Hirano and Kurland³), revealed their quite remarkable numbers and symmetric . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Visiting Scientist, Epidemiology Branch, National Institute of Neurological Diseases and Blindness of the National Institutes of Health, United States Public Health Service (Dr. Hirano).; From the Lucy and Henry L. Moses Research Laboratories of the Laboratory Division, Montefiore Hospital.

Footnotes
Submitted for publication May 15, 1962.

Aided by the Sandy Schneider Memorial Fund and Grant No. 73-7 of the National Multiple Sclerosis Society.

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