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Phosphatase in Cuneate Nuclei After Brachial Plexectomy
KEVIN D. BARRON, M.D.;
TURE O. TUNCBAY, M.D.
Arch Neurol. 1962;7(3):203-210.
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The importance of adequate stimulation for the maintenance and development of neural structures is exemplified by the phenomenon of transneuronal degeneration or atrophy. Transneuronal degeneration has been most convincingly demonstrated in the visual system.7 The partial deafferentation of a lateral geniculate body which follows enucleation of an eye leads to atrophy of those neurons deprived of sensory afferents. The number of geniculate nerve cells which die as a result of the surgical procedure depends upon the species concerned, the age of the animal operated on, and the length of postoperative survival.7-9,11,17
There is evidence that the phenomenon of Iransneuronal atrophy is a result of reduced protein turnover in cells deprived of stimulation.5,22 The functional connections of the lateral geniculate body, which is probably entirely dependent on the retinae for afferent supply, render it peculiarly susceptible to degeneration following surgical deafferentation. Nonetheless, transneuronal degeneration may be demonstrated in
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
From the Department of Neurology and Psychiatry, Northwestern University Medical School.
Footnotes
Received for publication Feb. 14, 1962.
This work was supported by Grant B-3018 of the National Institutes for Neurological Diseases and Blindness, U.S. Public Health Service, and Grant No. 276 of the National Multiple Sclerosis Society.
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