This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (17)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Relationship of Creatine-Creatinine Metabolism to Diet and Drugs

NIKOS BOURDAKOS, M.D.; STEWART WOLF, M.D.

Arch Neurol. 1962;6(6):439-450.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The mechanism and significance of creatinuria in the various forms of muscular dystrophy are still not clearly understood. Nevertheless, creatinuria persists as a striking indicator of biochemical disturbance. Creatine is known to figure in the energetics of muscular contraction in the transfer of high-energy phosphate bonds in the system ATP + CreatineADP + Creatine PO₄,¹ and the demonstration of appreciable amounts of creatine in the urine of people with muscular weakness, when they are eating a creatine-free diet, is widely used to support the diagnosis of primary myopathy.^2,3 A tolerance test after oral administration of creatine is considered to be of additional value.⁴ By now it is well-established that most forms of muscular dystrophy are associated with diminished creatinine excretion and pathological creatinuria of a degree, more or less proportional to the stage and severity of the disease.⁵ Moreover, it has been shown that the bulk of . . . [Full Text PDF of this Article]

Author Affiliations
OKLAHOMA CITY

Footnotes
Received for publication Aug. 30, 1961.

University of Oklahoma Medical Center.

American Philosophical Society Fellow in the Medical Sciences, 1954-1958 (Dr. Bourdakos).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?