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C. NORMAN SHEALY, M.D.; ELWOOD HENNEMAN, M.D.

Arch Neurol. 1962;6(5):374-386.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

This investigation is one of 3 studies^1,2 undertaken so explore the potentialities of high-intensity ultrasound in experimental neurology. Recently there has been increasing interest in this field. Techniques have been developed for producing lesions of constant size and shape at selected sites in the central nervous system.^3-6 Less attention has been paid to the effects of ultrasound on functioning neural circuits. Concurrent studies on the peripheral nerves of frogs¹ and cats² show that focused ultrasound will block axonal conduction reversibly or irreversibly, depending upon dosage. The smallest axons, the delta fibers and the C fibers, are most sensitive to irradiation.

In these experiments a segment of the cat's spinal cord was irradiated with ultrasound; the effects of the irradiation on the transmission of reflexes through that segment were followed oscillographically, and histological studies were carried out on the irradiated tissue.

Spinal reflexes, elicited and recorded . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Medical Acoustics Laboratory of the Department of Surgery (Neurosurgery), Massachusetts General Hospital, and the Department of Physiology, Harvard Medical School.

Research Fellow of the National Foundation for Infantile Paralysis and of the Neurosurgical Service, Department of Surgery, Massachusetts General Hospital (Dr. Shealy).

Footnotes
Received for publication Aug. 14, 1961.

This investigation was supported by Research Grant DA-49-007-MD-523 from the Department of the Army, Office of the Surgeon General, to Dr. H. T. Ballantine, Jr., Department of Surgery (Neurosurgery), Massachusetts General Hospital, and by Research Grant B-970 from the National Institutes of Health to Dr. E. Henneman.

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