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Effects on Learned Behavior and Correlated Hippocampal and Subcortical Slow-Wave Activity

W. R. ADEY, M.D.; D. O. WALTER, B.S.; D. F. LINDSLEY, B.A.

Arch Neurol. 1962;6(3):194-207.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Disruption in learned performance by subcortical lesions has been shown to occur from widely separated diencephalic and mesencephalic areas. With small lesions in a variety of subcortical structures, disruption of learned avoidance behavior is temporary (1955, Brady and Nauta¹¹), but, by contrast, in approach learning, longer-lasting effects have been described with lesions in the region of the entopeduncular nucleus in visual discriminative tasks (1960, Thompson²¹ ). With larger diencephalic lesions, persistence of cardiovascular and respiratory reflexes has been described (1959, Doty et al.¹²), but such larger lesions are associated with major behavioral defects in many areas, and discriminative motor performances are virtually lost.

We have been concerned in this study with restricted lesions in the region of the subthalamus and their effect on previously learned delayed response and T-maze performance. Our previous studies with somewhat larger lesions in this region have indicated interference with avoidance behavior in both . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

Footnotes
Received for publication July 20, 1961.

Brain Research Institute, University of California at Los Angeles, and Veterans Administration Hospitals, Long Beach and Los Angeles.

The studies described here were performed with assistance of Grant B-1883 from the U. S. Public Health Service and under contract AF49 (638)-686 with the Air Research and Development Command, U. S. Air Force.

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