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The Acute Phase

IRWIN FEIGIN, M.D.; NINA POPOFF, M.D.

Arch Neurol. 1962;6(2):151-160.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Until very recently, edema of the brain was generally thought to resemble that of other organs in consisting of the accumulation of fluid in an extracellular space, in addition to any intracytoplasmic changes. Recent electron microscopic studies have been interpreted as indicating that such extracellular space is virtually nonexistent, except possibly for a relatively constant zone no larger than 200 A. between adjacent cellular processes.^1-5 In edematous brains, electron microscopic studies disclosed swelling of a cellular process with a pale, clear cytoplasm.^6-9 These pale cellular processes have been interpreted as those of oligodendroglial cells,^1,9,10 as those of astrocytes,^2-6 or have not been otherwise identified.^{7,8 *} There is no disagreement, however, that it was these clear glial processes which were swollen in edema, and that there was no accumulation of fluid in an extracellular space.

In the light of these observations it was thought wise to review . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Departments of Pathology, New York University School of Medicine, and Bellevue Hospital.

Footnotes
Received for publication Aug. 24, 1961.

Presented in part before the American Association of Neuropathologists, June 10, 1961.

This study was supported in part by Research Grant H2872 from the National Heart Institute, and by Special Traineeship BT426 from the National Institute of Neurological Diseases and Blindness, U.S. Public Health Service, and forms part of a study of cerebrovascular diseases at Bellevue Hospital by the Cornell-New York University Study Group on cerebrovascular diseases.

Dr. Terry has informed us that he favors the interpretation that the pale glial processes are those of astrocytes. He further indicated that the tissues studied were probably gray matter.

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