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Histopathological Alterations

JAMES L. O'LEARY, M.D.; PAUL B. SAWIN, Ph.D.; SARAH LUSE, M.D.; A. BASIL HARRIS, M.D.; LAVERNE S. ERICKSON, M.D.

Arch Neurol. 1962;6(2):123-137.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There is no disease of animals directly comparable with human cerebellar ataxia, although conditions variously designated as agenesis, hypoplasia, and atrophy are described. Dow and Moruzzi⁶ have reviewed this topic. A condition in the cat called olivopontocerebellar atrophy was reported by Schut¹⁷ as one of a number of recorded instances of hypoplasia in this species. Earlier, that topic had been reviewed by Brouwer,³ who noted the association of cerebellar hypoplasia with atrophy of the inferior olives and of the pontine nuclei. Brouwer and Biermond⁴ designated this condition, too, as olivopontocerebellar atrophy. In relation to the present study, it is important that Brouwer³ described the deep cerebellar nuclei as showing a usual cell content. It is also relevant that in the ataxias of man and of cat the tissue studied represents an end stage of the pathological process. In the study reported herein, clinical manifestations become . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Departments of Anatomy and Pathology, and Divisions of Neurology and Neurosurgery, Washington University School of Medicine, and the Jackson Memorial Laboratory, Bar Harbor, Me.

Footnotes
Received for publication Aug. 28, 1961.

We acknowledge material aid from the Beaumont-May Institute of Neurology and Washington University School of Medicine.

Supported (in part) by Research Grant B722 from the National Institute of Neurological Diseases and Blindness, U.S. Public Health Service.

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