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William W. Beatty, PhD
Department of Psychiatry and Behavioral Sciences University of Oklahoma Health Sciences Center Oklahoma City, OK 73104

Roger A. Brumback, MD
Oklahoma City

Jean-Paul G. Vonsattel, MD
Belmont, Mass

Arch Neurol. 1997;54(12):1448.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Beatty and colleagues¹ described 5 patients with probable Alzheimer disease (AD)² who retained abilities to perform various complex cognitive tasks despite their dementias. Patient T (the trombone player) died in a nursing home approximately 3.5 years after the testing reported in the study. He required assistance in all activities of daily living and could no longer assemble his trombone by himself. However, if his trombone was assembled, placed into his hands, and raised to his lips, he could play notes and occasionally brief tunes.

After he died of cardiac arrest, his brain was removed and fixed in neutral-buffered formalin. The weight of patient T's fixed brain was 1125 g (normal range, 1300-1500 g). The results of the gross examination revealed only slight gyral atrophy. The results of the microscopic examination of cerebral sections revealed moderate to severe neuronal loss³ in the frontal and temporal poles, the entorhinal . . . [Full Text PDF of this Article]

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