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One Entity or 3? 1

Andrew Kertesz, MD, FRCPC

Arch Neurol. 1997;54(11):1427-1429.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PICK DISEASE (PiD), or circumscribed atrophy, as Pick called it, is like the proverbial elephant. When blind men are asked to define it, one feeling a leg calls it a tree, another touching the trunk declares it a snake, and a third encountering the body calls it a wall. The term means different things to different people. Pick disease is used either to designate clinically defined cases of progressive frontal and temporal degeneration, as was described by Pick,¹ or a pathologic entity defined histologically by the presence of argyrophilic globular inclusions (Pick bodies) and swollen achromatic neurons (Pick cells). Pick's initial patient with progressive aphasia and behavioral disturbance, and his subsequent patients with frontal lobe dementia and aphasia, underwent anatomical examination only. The histological description came later.² It also became apparent that cases of clinical PiD with frontal and temporal lobe atrophy may not show the typical histological . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario.

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