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Simple Partial Status Epilepticus and Antiglycolipid IgM Antibodies: Possible Epilepsy of Autoimmune Origin
Benoît Guillon, MD;
Eric de Ferron, MD;
Jean-René Feve, MD
Department of Neurology Hopital Laënnec CHU de Nantes, BP 1005 44035 Nantes Cedex 01, France
Jérome Honnorat, MD;
Christiane Caudie, MD
Lyon, France
Béatrice Nogues, MD;
Philippe Moreau, MD
Nantes
Arch Neurol. 1997;54(10):1194-1196.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Partial motor status epilepticus (PMSE) is characterized by motor seizures that "are so frequently repeated or so prolonged as to create a fixed and lasting condition."1 These epilepsies are associated with different types of diseases, including infectious, vascular, neoplastic, demyelinating, and traumatic ones as well as those of metabolic origin.2 We report a case of simple PMSE characterized by alternating or bilateral tonic contraction preceded by brief hallucinatory and forced-thinking episodes, which revealed Waldenström macroglobulinemia (WM). Although this lymphoproliferative disorder frequently involves the nervous system,3,4 this is apparently the first report of an association with PMSE and of complete recovery after chemotherapy. Moreover, the presence of antiglycolipid antibodies that have been reported to be potentially epileptogenic in rats5 and humans6 suggested that an autoimmune mechanism was responsible for status epilepticus occurrence.
A 64-year-old, right-handed man with an unremarkable medical history was first evaluated in January
. . . [Full Text PDF of this Article]
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