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Thomas A. Ala, MD; William H. Frey II, PhD
Ramsey Alzheimer's Research and Treatment Center 640 Jackson St St Paul, MN 55101-2595

H. Brent Clark, MD, PhD
University of Minnesota Medical School Minneapolis

Arch Neurol. 1996;53(10):958.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We have been following with much interest the articles in the ARCHIVES^1,2 regarding posterior cortical atrophy because case 5 in the original report¹ has been 1 of our clinic patients. This patient, who initially presented at age 54 years with visual complaints, recently died after a 13-year course of progressive dementia. Neuropathological examination has revealed the presence of Alzheimer disease with numerous senile plaques and neurofibrillary tangles involving the frontal, temporal, and parietal neocortex; the hippocampus; and the pyriform cortex. Although there were also numerous plaques involving the occipital cortex, only a few tangles were present in that region.

Our results are consistent with the neuropathological findings of Victoroff et al² and other investigators who have studied cases of posterior cortical atrophy^3,4 and suggest that Alzheimer disease should be considered as 1 of the primary causes in its differential diagnosis. With the caution that no occipital . . . [Full Text PDF of this Article]

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