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Richard A. Rudick, MD
The Mellen Center 9500 Euclid Ave Cleveland, OH 44195

Arch Neurol. 1995;52(9):849-850.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sadovnick and colleagues¹ reported exacerbation numbers and rates in 42 women with multiple sclerosis (MS) during and after 58 pregnancies resulting in live births. They concluded that "neither pregnancy nor the 6-month period after delivery is a risk factor for relapse in MS."¹ This conclusion is contrary to clinical experience and to numerous prior reports. Since the results are conflicting, I would appreciate clarification on two issues: the authors' use of the term prospective study and concerns about the power of their design to detect pregnancy-related differences in exacerbation rates.

Sadovnick et al¹ state that their data represent the first series of pregnant women with MS who were followed up prospectively, implying, through the use of the term prospective study, that the results are more reliable than those of prior studies. Specifically, they compared their study with a prior work by Birk et al² that reached . . . [Full Text PDF of this Article]

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