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David E. Comings, MD
Department of Medical Genetics National Medical Center, National Medical Center, 1500 F Duarte Rd, Duarte, CA 91010-0269

Arch Neurol. 1995;52(5):441-442.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

I was pleased to see the study by Gelernter et al¹ concerning the role of the dopamine D₂ receptor (DRD2) gene in Tourette syndrome (TS) because the authors so nicely verified our previous studies demonstrating a role the DRD2 gene in TS and because they illustrated some of the issues concerning association vs linkage studies in neuropsychiatric disorders. I felt that it was necessary to write this letter because the way in which the results were reported may have left the wrong impression with readers who are not familiar with the field.

In 1991, we² reported that the prevalence (percent with the 11 or 12 genotype) of the D₂A1 allele in 147 non-Hispanic white TS probands was 44.9%. This was significantly greater than the prevalence of 24.5% in 314 non-Hispanic white control subjects (P =.0001). Subsequently, we³ reported on an enlarged set of 220 . . . [Full Text PDF of this Article]

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