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Arndt Rolfs, MD; Rainer Schaub, MD
Department of Neurology University of Rostock PO Box 100888 Gehlsheimerstrasse 20 18055 Rostock, Germany

Arch Neurol. 1995;52(3):229.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Patients admitted with cerebral toxoplasmosis tend to respond poorly to antitoxoplasmic drug therapy; therefore, primary prophylaxis for patients at high risk would seem attractive. Primary prophylaxis with trimethoprim-sulfamethoxazole against cerebral toxoplasmosis has recently been shown to be efficacious.¹ However, long-term therapy with antitoxoplasmic drugs has frequent side effects; patients with a low risk of developing cerebral toxoplasmosis may not benefit from primary prophylaxis.

In a retrospective analysis of the patients seen in our center between January 1, 1986, and June 1, 1992, we tried to find predictors of subsequent Toxoplasma encephalitis. Only patients with no clinical indications of neuropsychiatric disturbances and computed tomographic or magnetic resonance imaging scans showing no focal lesions were included in the study. All patients underwent complete clinical examination, lumbar puncture, and computed tomographic scanning at intervals of 6 months.

All 45 patients who were eligible for the longitudinal observation were homosexual men, with a . . . [Full Text PDF of this Article]

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