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Vladimir Hachinski, MD, FRCP(C), DSc(Med)
Department of Clinical Neurological Sciences University Hospital PO Box 5399 339 Windermere Rd London, Ontario, Canada N6A

Arch Neurol. 1995;52(10):941.

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In reply

Garcia and Gilman make some very good points about the selection biases inherent in hospital and retrospective studies.

I do not have enough knowledge about the primary data on this subject to hold a strong opinion. If Garcia and Gilman are right that the natural history of cysticercosis is much more benign than portrayed and if uncertainty remains about the efficacy of therapy, then a randomized, controlled clinical trial would, indeed, be preferable. One would want to make sure, however, that firm stopping rules were in place and that regular monitoring by a safety committee would assure that patients were not being harmed and that the study would not go beyond the point of reasonable certainty about a therapeutic effect. . . . [Full Text PDF of this Article]

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