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edited by Sheryl A. Scott, 441 pp, $80, New York, NY, Oxford University Press, 1992.

Robert W. Doty, PhD, Reviewer
Rochester, NY

Arch Neurol. 1994;51(6):539.

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The title lays claim to more than it intends, perhaps as an example of the close immersion of the authors in their trade. What the book actually covers, in a commendably lucid yet thorough fashion, is the manner in which neurons of mammalian dorsal root ganglia mediate the precision of connection between peripheral sources of excitation and the relevant central target(s). As the introductory chapter notes, there are more than 40 differing types of primary afferent units serving, for example, muscle spindles, thermoreceptors, hair displacement detectors, and a variety of nociceptors. Arranging and maintaining these multiple sources of input to produce appropriately integrated reflex outcomes and distinct qualities of sensation are dependent on an intricate chemical choreography. In large measure, this book in its 19 chapters is an examination of various growth factors that, via axoplasmic transport, nourish the connectivity and its subtle specificity in various stages of life.

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