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J. Río, MD; J. Montalban, MD; M. Tintoré, MD; A. Codina, MD
Servei de Neurología Hospital General Universitari Vall d'Hebrón 08035 Barcelona, Spain

M. R. Malinow, MD
Beaverton, Ore

Arch Neurol. 1994;51(12):1181.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent articles^1,2 on the association of vitamin B₁₂ deficiency and multiple sclerosis (MS) have revived interest in vitamin B₁₂ metabolism in MS. In both disorders, demyelination is a noteworthy feature; however, MS is clearly different from vitamin B₁₂ deficiency. Vitamin B₁₂ deficiency is usually a disorder of the middle or late stage of life and rarely occurs in the age range typical for the presence of MS.³ Mild but significant macrocytosis has been found in patients with MS compared with an age- and sex-matched neurological control group.⁴ Significant lowering of the serum vitamin B₁₂ concentration has also been reported in patients with MS.⁵ This association, however, remains unclear because convincing evidence of clinical abnormalities attributable to vitamin B₁₂ deficiency in patients with MS was not documented by the authors. Although the serum vitamin B₁₂ assay is an extremely sensitive . . . [Full Text PDF of this Article]

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