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vol 47, GABA Synaptic Transmission: Molecular, Pharmacological and Clinical Aspects, edited by Giovanni Biggio, Alessandra Concas, and Erminio Costa, 493 pp, $99, New York, NY, Raven Press, 1992.

Jean M. Bidlack, PhD, Reviewer
Rochester, NY

Arch Neurol. 1994;51(1):11-12.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This volume summarizes the data on GABA (-aminobutyric acid) receptors presented during the Seventh Sardinian Conference on Neuroscience, held in Domus De Maria, Sardinia, Italy, inJune 1991. This book is a comprehensive report of the most up-to-date information about the pharmacology and physiopathology of GABA_A receptors in the mammalian central nervous system. The 44 chapters included in this volume are divided in different sections ranging from molecular biology to molecular and clinical pharmacology and to therapeutic approaches.

One of the important findings in the pharmacology of the central GABAergic transmission has been the discovery that the GABA_A ionophore-receptor complex contains specific recognition sites for several drugs with different chemical profiles and often opposite pharmacologic actions. These studies suggest that the central GABAergic transmission is directly or indirectly involved not only in the pharmacology but also in the neurochemistry and physiopathology of a variety of neurologic and psychiatric diseases . . . [Full Text PDF of this Article]

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