This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ali H. Rajput, MBBS, FRCPC

Arch Neurol. 1993;50(6):651-652.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There are three main considerations in the cause of Parkinson's disease (PD)—genetic, environmental, and environmental trigger in genetically predisposed individuals. Literature on the subject is voluminous, but the scientific impact of different studies varies widely.

Parkinson syndrome (PS) is diagnosed when two of the three—bradykinesia, rigidity, and resting tremor—are detected. Parkinson's disease, which accounts for a majority of cases,^1-5 is diagnosed when Lewy body (LB) pathology is noted.⁶ Because the clinical diagnosis of PD may be incorrect in a large proportion,^5,7 studies based on only clinical assessment include several diverse variants of PS rather than single disease entity. It is reasonable to assume that the cause for all different variants of PS is not the same.

For a critical analysis of the literature, the following well-known facts must be taken into consideration: (1) PD is ubiquitous; (2) the mean onset age is approximately 62 years, the frequency . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine (Neurology), Royal University Hospital, Saskatoon, Saskatchewan.

Footnotes
Accepted for publication December 10, 1992.

Reprint requests to Department of Medicine (Neurology), Royal University Hospital, Saskatoon, Saskatchewan, Canada 27N OXO (Dr Rajput).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?