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Ruggero Capra, MD; Nicoletta Marciano, MD
Department of Neurology

Roberto Gasparotti, MD
Department of Radiology University of Medicine, Brescia Piazza Spedali Civili 1 25123 Brescia, Italy

Arch Neurol. 1993;50(6):570-571.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—We would like to thank Goodkin for his very interesting comments concerning our recent article entitled "Gadolinium-Pentetic Acid Magnetic Resonance Imaging in Patients With Relapsing Remitting Multiple Sclerosis."¹ He clearly demonstrated that in serial magnetic resonance imaging studies of patients with multiple sclerosis, repositioning errors can be responsible in the apparent development of new enhancing plaques and, in general, of an overestimation of the total number of plaques.

We agree with his observations and conclusions that even small repositioning errors could affect the overall evaluation of the brain disease activity, since the appearance, disappearance, enlargement, or reduction in size of a single lesion could be erroneously attributed to a biologic phenomenon rather than to a technical problem. In our study, head repositioning, made with the help of a laser light marker, was based on a direct confrontation of the current reference T₁-weighted midline sagittal image, . . . [Full Text PDF of this Article]

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