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A Study of the Effects of Experimental Section of the Corpus Callosum upon Pentylenetetrazol-Induced Convulsions

J. J. SEGUIN, Ph.D.; N. A. FRETZ, M.D.; S. J. MANAX, B.Sc.; G. W. STAVRKY, M.D.

Arch Neurol. 1961;5(3):314-319.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

It was shown previously that cats and white rats which had undergone removal of one cerebral hemisphere or of a frontal lobe, including the motor cortex, were more susceptible to pentylenetetrazol convulsions than unoperated animals.^1-3 The question remained as to which regions of the central nervous system were sensitized by these operations. An answer to this question was sought in the present investigation by testing the effects of pentylenetetrazol on Sprague-Dawley rats in which partial denervation was confined to cerebral cortical neurones. This was accomplished by sectioning the corpus callosum.

Experimental Procedure

Male Sprague-Dawley rats were divided randomly into 3 groups. In one group the corpus callosum was sectioned aseptically under pentobarbital (Nembutal) anesthesia, one control group was left intact, and in another a sham trepanation was performed under identical conditions with the corpus callotomy.

One to 5 months after the operation, the CD₅₀ (median convulsant dose) . . . [Full Text PDF of this Article]

Author Affiliations
LONDON, ONT. CANADA

Department of Physiology, Faculty of Medicine, University of Western Ontario. Fellow of the Muscular Dystrophy Association of Canada (Dr. Seguin); Lederle Medical Student Research Fellow (Dr. Fretz); Studentship of the Defence Research Board of Canada (Mr. Manax).

Footnotes
Received for publication Feb. 15, 1961.

Supported by a grant from the National Research Council of Canada.

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