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Some Properties of Single Epileptic Neurons
ARTHUR A. WARD, JR., M.D.;
RICHARD P. SCHMIDT, M.D.
Arch Neurol. 1961;5(3):308-313.
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Previous studies describing the electrical activity at an epileptogenic focus in the experimental animal and man by means of scalp or pial recording with gross electrodes have generally confirmed the concept that abnormal neuronal hyperactivity is the fundamental defect in epilepsy. However, such techniques have been limited by the fact that the potentials recorded are generated by graded response neuronal membranes which, by current concepts, are largely assigned to cortical dendrites. Such studies thus do not yield data upon the activity of those portions of cortical cells generating all-or-none signals. In recent years, microelectrode techniques have been devised which permit the recording of electrical activity of single neurons within the central nervous system. Studies utilizing this technique have therefore been undertaken over the past 8 years to provide information regarding the activity of single nerve cells in epileptogenic foci.
Schmidt, Thomas, and Ward2 carried out microelectrode studies of single
. . . [Full Text PDF of this Article]
Author Affiliations
SEATTLE
Footnotes
Received for publication March 3, 1961.
Division of Neurosurgery, University of Washington School of Medicine.
Presented in part at the 81st Annual Meeting of the American Neurological Association, June, 1956.
Dr. Schmidt's present address: Division of Neurology, University of Florida College of Medicine, Gainesville, Fla.
Supported in part by a grant (B-193) from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, U.S. Public Health Service.
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