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Action of Bishydroxycoumarin

WARREN H. KEMPINSKY, M.D.; WILLIAM R. BONIFACE, M.D.; JOSE B. A. KEATING, M.D.; WILLY WEINSTEIN, M.D.

Arch Neurol. 1961;5(3):275-278.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The anticoagulant drugs are currently in common use in the treatment of ischemic cerebral vascular disease. One of the more widely accepted criteria for this form of therapy is the "intermittent insufficiency syndrome" of the internal carotid or of the vertebral-basilar arterial system. Although the most obvious effect of these drugs is prevention of intravascular thrombosis, the mechanism of their effect in preventing the repeated transient episodes of neurologic dysfunction, which comprise the intermittent insufficiency syndromes, is a more obscure property. This property is not readily explained by their interference with the blood coagulation mechanism. Fisher and Cameron have most ably expressed this dilemma, and we quote them: "In trying to explain the events in this case, it is difficult to picture exactly a process which could lead to transient cerebral attacks and yet be prevented by anticoagulant therapy."¹

Several concepts have been proposed which might explain these transient . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Neurology Section and the Neurology Research Laboratories of the Washington University unit, St. Louis City Hospital, and of the Division of Neurology, School of Medicine, Washington University, St. Louis.

Dr. Kempinsky presently is at Division of Neurology, Department of Medicine, Marquette University School of Medicine, Milwaukee County Hospital.

Footnotes
Received for publication May 26, 1961.

National Multiple Sclerosis Society Fellow (Dr. Boniface), and Institute of Medical Education and Research Fellow in Neurology (Dr. Keating).

This investigation was supported in part by Grant B-1364, National Institute of Neurological Diseases and Blindness, National Institutes of Health, U.S. Public Health Service.

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