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Boyd A. Dwyer, MD; Richard F. Mayer, MD
Department of Neurology

Sunhee C. Lee
Division of Neuropathology University of Maryland School of Medicine Baltimore, MD 21201

Arch Neurol. 1992;49(5):440.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Nemaline (rod) myopathy associated with human immunodeficiency virus (HIV) infection has been reported in male patients at risk for the infection.^1,2

Report of a Case.

—We report the case of a 23-year-old woman who presented with a 6-month history of progressive weakness. Neuromuscular examination showed marked proximal muscle weakness and an exaggerated lordotic posture. An electromyogram was mildly abnormal, the serum creatine kinase concentration was borderline elevated, metabolic study results were normal, and family history was negative. A deltoid muscle biopsy specimen revealed prominent random atrophic myofibers containing numerous intracytoplasmic rod bodies, especially in type 1 fibers. No inflammatory response was present. Electron microscopy revealed the bodies to be electron-dense filamentous accumulations that had a crystalline periodicity on cross-section characteristic of nemaline rods. No viral particles were noted. A serum HIV titer drawn at the time of the biopsy was positive by enzyme-linked immunosorbent assay and . . . [Full Text PDF of this Article]

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