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Jouko I. T. Isojärvi, MD, PhD
Department of Neurology University of Oulu SF-90220 Oulu, Finland

Arch Neurol. 1992;49(2):134-135.

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In Reply.

—In his letter, Herzog brings attention to the question about the most relevant testosterone measurement with regard to reproductive and sexual function in men with epilepsy. The question is important. It is well known that men with epilepsy suffer from reproductive dysfunction and hyposexuality more often than the average population of similar age.^1-4 Both epilepsy per se and the antiseizure medications have been attributed as etiologic factors.^3-5

It seems clear that antiseizure medications are associated with the development of hyposexuality in patients with epilepsy. Impotence or decreased libido were found in 11% to 22% of patients with epilepsy after starting single-drug treatment with carbamazepine, phenytoin, phenobarbital, or primidone, suggesting a drug-induced hyposexuality.⁶

It seems clear that antiseizure medications are associated with the development of hyposexuality in patients with epilepsy. Impotence or decreased libido were found in 11% to 22% of patients with epilepsy after starting single-drug treatment with carbamazepine, phenytoin, . . . [Full Text PDF of this Article]

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