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Jeremy D. Schmahmann, MD
Department of Neurology Massachusetts General Hospital Fruit Street Boston, MA 02114

Arch Neurol. 1992;49(12):1230.

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In Reply.

—I thank Botez for his comments. In attempting to establish a causal relationship between lesions of the cerebellum and disturbances of higher function, it is important to know the nature and extent of the cerebellar lesion and also the integrity of the cerebral hemispheres in any given individual. This is particularly true in patients with degenerative cerebellar syndromes, because their cerebral hemispheres are frequently abnormal when studied post mortem. Similarly, it would seem that the study of intoxications of the nervous system is suboptimal because other regions of the cerebral hemispheres are likely to be affected as well. The neuropsychologic performance of patients with chronic unilateral cerebellar damage appears to be unimpaired, according to a preliminary report by Botez and Botez.¹ It would be helpful to know the lesion site in these patients, because behavioral manifestations in animals seem to vary depending on the part of the . . . [Full Text PDF of this Article]

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