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  Vol. 48 No. 6, June 1991 TABLE OF CONTENTS
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Machado-Joseph Disease or Not?

David M. Dawson, MD
Neurology Service Brockton-West Roxbury Veterans Administration Medical Center 1400 VFW Parkway West Roxbury, MA 02132

Arch Neurol. 1991;48(6):570.

Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Eto and coworkers1 describe 12 patients with a hereditary ataxia they believe most closely resembles spinopontine atrophy as described by Boiler and Segarra2 in a large Rhode Island kindred, the family W, of English extraction. I have had contact with this family. One patient from the family actually appears in the literature twice, as patient 2 in the report on spinopontine atrophy by Pogacar et al,3 and again as a patient with olivopontocerebellar atrophy in the writings of Huang and Plaitakis.4 The distinctions between spinopontine atrophy and olivopontocerebellar atrophy seem slight indeed on clinical or pathologic grounds.

Eto et al1 compare spinopontine atrophy to Machado-Joseph disease and note the many similarities. Machado-Joseph disease is distinctive primarily in its geographic source. Many hundreds of patients and nonaffected family members of Azorean lineage have been examined, and cultured cell lines established from those individuals . . . [Full Text PDF of this Article]



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