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Howard S. Maker, MD
Department of Neurology Mt Sinai School of Medicine Beth Israel Medical Center 1st Avenue at 16th Street New York, NY 10003

Arch Neurol. 1991;48(6):569.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Rozental et al¹ reported the effect of chemotherapy on the uptake of fluorodeoxyglucose F18 into human gliomas determined by positron emission scanning. They confirmed previous reports that glucose uptake correlates with the histological degree of malignancy and, as had others, attributed the increased uptake to an intrinsically high aerobic glycolytic rate in tumors. Although it is true that most neoplastic cells have a higher rate of aerobic glycolysis (metabolism when fully oxygenated) than their nonneoplastic cells of origin²; it is doubtful that the metabolism of malignant gliomas is truly aerobic. Several years ago we noted that the metabolic enzyme profiles of several experimental neoplasms did suggest a high glycolytic capacity,³ but that changes in glucose, lactate, and high-energy phosphates during ischemia in an experimental ependymoblastoma implanted in mouse brain indicated that the tumors functioned at less than adequate oxygen levels.^4,5 Indeed, the high . . . [Full Text PDF of this Article]

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