This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Didier Leys, MD; Marc Steinling, MD; Jean-Pierre Pruvo, MD; Henri Petit, MD
Service de Neurologie B Hôpital B University of Lille 59037 Lille, France

Philip Scheltens, MD; Frederik Barkhof, MD
Dienst Neurologie Vrije Universiteit Ziekenhuis PO Box 7057 1007 Amsterdam, the Netherlands

Arch Neurol. 1991;48(5):469-470.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—The significance of white matter and periventricular hyperintensities and the question whether they differ between patients with Alzheimer's disease and age-matched controls remains to be discussed. We found no difference between patients with Alzheimer's disease and normal subjects.¹ Fazekas and McDonald point out possible methodological bias we would like to discuss in the following nine points:

(1) We agree with them that including magnetic resonance imaging scans of lower quality for calculation of interobserver agreement might have lowered values in the evaluation of Fazekas' scoring system.² We have again calculated among the 27 high-quality magnetic resonance images and we found very small improvements (periventricular hyperintensity, 0.44 instead of 0.43; white matter hyperintensity, 0.58 instead of 0.50). Kozachuck et al³ found higher values of than we did but most of their subjects had very low periventricular and white matter hyperintensity scores; we think . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?